Publications of My Classmates

tc

2017/07/28

Categories: trivial notes Tags: bibliography

“Explain it like I’m five”

For a starter, it might be interesting to see what my classmates (undergrad period) are doing with their research, and try to explain it with my shameless, shallow, short-sighted, lack-of-common-sense point of view.


  1. Natural selection can favor the evolution of ratchet robustness over evolution of mutational robustness (1)
    • I read about the abstract and didn’t get it. What’s Muller’s ratchet and epistasis?

  1. Resting-state functional connectivity between the dorsal anterior cingulate cortex and thalamus is associated with risky decision-making in nicotine addicts (2)
    • Conclusion: people smoke more tends to make bold moves. they used fMRI to show that bold moves are associated with
      • heavy smoker
      • stronger connectivity between some brain areas
    • What is “risk level-related activation”?

  1. Simulating Large-Scale Conformational Changes of Proteins by Accelerating Collective Motions Obtained from Principal Component Analysis (3)
    • Molecular dynamics, great…
    • So it uses modes found in PCA to guide structural sampling, which solves some kind of bias called “tip effect” in the elastic models.

Reference

1. Lan Y, Trout A, Weinreich DM, Wylie CS (2017) Natural selection can favor the evolution of ratchet robustness over evolution of mutational robustness. bioRxiv:121087.

2. Wei Z, et al. (2016) Resting-state functional connectivity between the dorsal anterior cingulate cortex and thalamus is associated with risky decision-making in nicotine addicts. Scientific reports 6:21778.

3. Peng J, Zhang Z (2014) Simulating Large-Scale Conformational Changes of Proteins by Accelerating Collective Motions Obtained from Principal Component Analysis. J Chem Theory Comput 10(8):3449–3458.

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